Hydrochloric Acid → HCID 67275467, compound

HRID 1696904Notes

Reaction equation

HRID 1696904 reaction equation
[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:31])[C:10]([C:26]([O:28]CC)=[O:27])=[CH:11][N:12]3[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=3[O:24][CH3:25])=[C:7]([CH3:32])[CH:6]=2)[CH2:4][CH2:3][CH2:2]1.O.[OH-].[Li+].Cl>O1CCOCC1>[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:31])[C:10]([C:26]([OH:28])=[O:27])=[CH:11][N:12]3[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=3[O:24][CH3:25])=[C:7]([CH3:32])[CH:6]=2)[CH2:2][CH2:3][CH2:4]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 67275296HCID 67275296, compound

Product 1

HCID 67275467HCID 67275467, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
60 °C

Procedure

A solution of EXAMPLE 18A (0.320 g) in 1,4-dioxane (7.3 mL) was treated with lithium hydroxide monohydrate (0.0919° g), heated at 60° C. for 18 hours then cooled, poured into 1M HCl, and filtered to provide the desired product.

Workup

  1. temperaturethen cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-7e0d7045a6a241398f8d493fb4a4a0cb
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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