HCID 67275458, compound → HCID 11778294, compound

HRID 1696908Notes

Reaction equation

HRID 1696908 reaction equation
C(OC([NH:8][CH:9]1[CH2:12][N:11]([C:13]2[N:22]=[C:21]3[C:16]([C:17](=[O:30])[C:18]([C:27]([OH:29])=[O:28])=[CH:19][N:20]3CCC#N)=[CH:15][C:14]=2[F:31])[CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:8][CH:9]1[CH2:12][N:11]([C:13]2[N:22]=[C:21]3[C:16]([C:17](=[O:30])[C:18]([C:27]([OH:29])=[O:28])=[CH:19][NH:20]3)=[CH:15][C:14]=2[F:31])[CH2:10]1

Participants

3

Reactant 1

HCID 67275458HCID 67275458, compound

Product 1

HCID 11778294HCID 11778294, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of EXAMPLE 20B (0.12 g) in trifluoroacetic acid (6 mL) was stirred for 10 minutes and concentrated; and the concentrate was azeotroped with toluene to provide the desired product. NMR (300 MHz, DMSO-d6) δ 8.51 (s, 1H), 8.03 (m, 1H), 4.58 (m, 2H), 4.26 (m, 2H), 4.16 (br s, 1H).

Workup

  1. concentrationconcentrated
  2. customand the concentrate was azeotroped with toluene

Sources & evidence

ORD record
ord-df12ccf179c7402eac30d671a06477e2
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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