Citric Acid → HCID 67274950, compound

HRID 1696915Notes

Reaction equation

HRID 1696915 reaction equation
[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:31])[C:10]([C:26]([O:28]CC)=[O:27])=[CH:11][N:12]3[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=3[O:24][CH3:25])=[C:7]([CH3:32])[C:6]=2[F:33])[CH2:4][CH2:3][CH2:2]1.[Li+].[OH-].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>C1COCC1>[N:1]1([C:5]2[N:14]=[C:13]3[C:8]([C:9](=[O:31])[C:10]([C:26]([OH:28])=[O:27])=[CH:11][N:12]3[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][C:17]=3[O:24][CH3:25])=[C:7]([CH3:32])[C:6]=2[F:33])[CH2:2][CH2:3][CH2:4]1

Participants

5

Reactant 3

HCID 311Citric AcidHCID 3939Lithium HydroxideHCID 67275150HCID 67275150, compound

Product 1

HCID 67274950HCID 67274950, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 5A (250 mg) in THF (30 mL) dichloromethane (10 mL) was treated with 1M LiOH (15 mL), stirred for 18 hours, treated with 10% citric acid, and extracted with dichloromethane; and the extract was concentrated.

Workup

  1. extractionextracted with dichloromethane
  2. concentrationand the extract was concentrated

Sources & evidence

ORD record
ord-2a375b385bf4484baffd0cae669c64ed
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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