HCID 67275514, compound → HCID 10244293, compound

HRID 1696927Notes

Reaction equation

HRID 1696927 reaction equation
C([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[N:13]=2)[C:8](=[O:20])[C:7]([C:21]([O:23]CC)=[O:22])=[CH:6]1)(C)(C)C>C(O)C.Cl.C(OCC)C>[O:20]=[C:8]1[C:9]2[C:14](=[N:13][C:12]([N:15]3[CH2:16][CH2:17][CH2:18][CH2:19]3)=[CH:11][CH:10]=2)[NH:5][CH:6]=[C:7]1[C:21]([OH:23])=[O:22]

Participants

5

Reactant 1

HCID 67275514HCID 67275514, compound

Product 1

HCID 10244293HCID 10244293, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of Example 74A (63.2 mg) in ethanol (2.5 mL) and 6M HCl (2.5 mL) was heated in a sealed tube at 130° C. for 18 hours then cooled, diluted with diethyl ether, and filtered. NMR (300 MHz, DMSO-d6) δ 8.43 (s, 1H), 8.22 (m, 1H), 6.80 (m, 1H), 3.55 (m, 4H), 2.00 (m, 4H).

Workup

  1. temperaturethen cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-c5c8c1ade1c942509877e988b62dd997
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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