Lithium Hydroxide → HCID 67275373, compound

HRID 1696928Notes

Reaction equation

HRID 1696928 reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:40])[C:19]([C:35]([O:37]CC)=[O:36])=[CH:20][N:21]3[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=3[O:33][CH3:34])=[CH:16][C:15]=2[F:41])[CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Li+].[OH-]>C1COCC1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:40])[C:19]([C:35]([OH:37])=[O:36])=[CH:20][N:21]3[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][C:26]=3[O:33][CH3:34])=[CH:16][C:15]=2[F:41])[CH2:10]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67275099HCID 67275099, compound

Product 1

HCID 67275373HCID 67275373, compound

Reagents, catalysts & solvents 2

HCID 311Citric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of Example 75A (678 mg) and 1M LiOH (4.75 mL) in THF (20 mL) was stirred for 18 hours, diluted with 10% citric acid, and extracted with dichloromethane. The extract was dried (Na2SO4), filtered, and concentrated.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialThe extract was dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-23baee38671742388bc85c8b425aa447
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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