Hydrochloric Acid → HCID 67275342, compound

HRID 1696947Notes

Reaction equation

HRID 1696947 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:22][CH:21]([OH:23])[CH:20]([NH2:24])[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8](CCC#N)[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[NH2:24][C@H:20]1[C@@H:21]([OH:23])[CH2:22][N:18]([C:11]2[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][NH:8]3)=[CH:13][C:12]=2[F:17])[CH2:19]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67275567HCID 67275567, compound

Product 1

HCID 67275342HCID 67275342, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of EXAMPLE 228A (0.1 g) in ethanol (1 mL) at 25° C. was treated with 1N NaOH (1 mL), stirred for 18 hours at 50° C., cooled to 25° C., neutralized using 10% HCl, and filtered. NMR (300 MHz, DMSO-d6) δ ppm 3.7-4.5 (m, 6H), 8.0 (d, 1H), 8.42 (bs, 1H), 8.49 (d, 2H), 13.41 (m, 1H).

Workup

  1. temperaturecooled to 25° C.
  2. filtrationfiltered

Sources & evidence

ORD record
ord-3da8abae6c8a41d4b46acab68d5e695e
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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