Lithium hydroxide, monohydrate → HCID 67275522, compound

HRID 1696948Notes

Reaction equation

HRID 1696948 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:22][CH:21]([OH:23])[CH:20]([NH:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][C:34]=2[O:41][CH3:42])[CH:7]=1)=[O:5])C.O.[OH-].[Li+]>O1CCCC1.O>[CH2:25]([NH:24][CH:20]1[CH:21]([OH:23])[CH2:22][N:18]([C:11]2[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[CH2:32][C:33]3[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][C:34]=3[O:41][CH3:42])=[CH:13][C:12]=2[F:17])[CH2:19]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67275014HCID 67275014, compound

Product 1

HCID 67275522HCID 67275522, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 244A (0.049 g) in tetrahydrofuran (3 mL) at 25° C. was treated with a solution of lithium hydroxide monohydrate (0.048 g) in water (3 mL), stirred for 18 hours, concentrated, acidified with HCl (2N in diethyl ether), and filtered.

Workup

  1. concentrationconcentrated
  2. filtrationfiltered

Sources & evidence

ORD record
ord-069bfd69e40446eab1a9d46478df17a4
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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