反应详情

1.0 g of 5-amino-4-methyl-2-(2,2,2-trifluoro-1-trifluoromethylethoxy)pyridine was introduced to 10 ml of N,N-dimethylformamide, and 0.56 g of N-chlorosuccinic acid imide was added thereto at room temperature. The resulting solution was heated to 60 degree centigrade, stirred for 1 hour, and then poured into water and extracted with ethyl acetate. The solution was dried over anhydrous magnesium sulfate, and then the solvent was removed under a reduced pressure to obtain a residue. The resulting residue was purified by silica gel column chromatography using an eluent (development solvent; hexane:ethyl acetate=10:1) to obtain 0.50 g of the desired product (Yield: 44%) as brown oil.

1. additionwas added
2. customat room temperature
3. temperatureThe resulting solution was heated to 60 degree centigrade
4. extractionextracted with ethyl acetate
5. dry with materialThe solution was dried over anhydrous magnesium sulfate
6. customthe solvent was removed under a reduced pressure
7. customto obtain a residue
8. customThe resulting residue was purified by silica gel column chromatography