Hydrochloric Acid → HCID 67019394, compound

HRID 1697018Notes

Reaction equation

HRID 1697018 reaction equation
FC(F)(F)C(O)=O.C(OC(=O)[NH:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[N:29]=[C:28]3[C:24]([N:25]=[CH:26][N:27]3[C@@H:30]3[CH2:34][C@H:33]([NH:35][C:36](=[O:39])[CH2:37][CH3:38])[C@@H:32]([OH:40])[C@H:31]3[OH:41])=[C:23]([NH:42][CH2:43][CH:44]([C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)[C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)[N:22]=2)[CH2:17][CH2:16]1)(C)(C)C.[ClH:58]>CO>[ClH:58].[ClH:58].[NH2:14][CH:15]1[CH2:20][CH2:19][N:18]([C:21]2[N:29]=[C:28]3[C:24]([N:25]=[CH:26][N:27]3[C@@H:30]3[CH2:34][C@H:33]([NH:35][C:36](=[O:39])[CH2:37][CH3:38])[C@@H:32]([OH:40])[C@H:31]3[OH:41])=[C:23]([NH:42][CH2:43][CH:44]([C:45]3[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=3)[C:51]3[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=3)[N:22]=2)[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66631021HCID 66631021, compound

Product 1

HCID 67019394HCID 67019394, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

{1-[9-((1R,2S,3R,4S)-2,3-Dihydroxy-4-propionylamino-cyclopentyl)-6-(2,2-diphenyl-ethyl-amino)-9H-purin-2-yl]-piperidin-4-yl}-carbamic acid tert-butyl ester trifluoroacetate (0.02 g, 0.03 mmol) is dissolved in HCl (1 ml of a 1.25 M solution in methanol) and allowed to stand at room temperature overnight. The solvent is removed in vacuo to yield the titled compound.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-2dc7f729a1184e21b7f6a8f3a86329df
Source dataset
uspto-grants-2012_04
Patent number
US08163754B2

Reaction notes

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