反应详情

To a solution of 4-formylbenzenesulfonyl chloride (1.0 g) in DCM (10 mL) was added NaHCO3 (sat'd aq, 10 mL) followed by 1-methyl-piperazine (0.6 mL). The reaction mixture was vigorously stirred for 1 h, the organic layer separated, and the aqueous layer extracted with DCM (2×20 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure to give 4-(4-methyl-piperazine-1-sulfonyl)-benzaldehyde (1.28 g) without further purification.

1. customthe organic layer separated
2. extractionthe aqueous layer extracted with DCM (2×20 mL)
3. washThe combined organic extracts were washed with brine
4. dry with materialdried over anhydrous Na2SO4
5. filtrationfiltered
6. customevaporated under reduced pressure