2-Propanol, 1-amino-2-methyl- → HCID 59846167, compound

HRID 1697082Notes

Reaction equation

HRID 1697082 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)=[O:2].C([O-])(O)=O.[Na+].[NH2:18][CH2:19][C:20]([CH3:23])([OH:22])[CH3:21]>CO>[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:18][CH2:19][C:20]([OH:22])([CH3:23])[CH3:21])(=[O:11])=[O:10])=[CH:5][CH:4]=1)=[O:2]

Participants

5

Reactant 3

HCID 951022-Propanol, 1-amino-2-methyl-HCID 516892Sodium BicarbonateHCID 27592104-Formylbenzene-1-sulfonyl chloride

Product 1

HCID 59846167HCID 59846167, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 4-formyl-benzene sulfonyl chloride (1.0 g) in MeOH was added NaHCO3 (0.425 g), followed by 1-amino-2-methylpropan-2-ol (0.566 g). The reaction mixture was stirred for 1 h at RT, then filtered through Celite and the solvent removed under reduced pressure to provide 4-formyl-N-(2-hydroxy-2-methylpropyl)-benzene sulfonamide.

Workup

  1. filtrationfiltered through Celite
  2. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-84e19fda845941afaeadf147790c95b7
Source dataset
uspto-grants-2012_04
Patent number
US08163906B2

Reaction notes

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