反应详情

2.48 g hydroxylamine-hydrochloride and 5.68 ml triethylamine are added to 4.10 g of 6-bromo-2-cyano-naphthalene in 100 ml of ethanol and the reaction mixture is refluxed for four hours. After cooling to ambient temperature the solvent is distilled off in vacuo using the rotary evaporator and the flask residue is divided between water and ethyl acetate. The aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate and evaporated down.

1. temperaturethe reaction mixture is refluxed for four hours
2. distillationis distilled off in vacuo
3. customthe rotary evaporator
4. extractionThe aqueous phase is extracted with ethyl acetate
5. customthe combined organic phases are dried on magnesium sulphate
6. customevaporated down