Lithium Hydroxide → HCID 66771983, compound

HRID 1697768Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][N:14]([C:16]2[N:20]([CH2:21][C:22]3[N:26]([CH3:27])[CH:25]=[N:24][CH:23]=3)[N:19]=[C:18]([CH3:28])[CH:17]=2)[C@H:13]([C:29]([O:31]C)=[O:30])[CH2:12]1)(=[O:10])=[O:9].[OH-].[Li+:34]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C@H:11]1[CH2:15][N:14]([C:16]2[N:20]([CH2:21][C:22]3[N:26]([CH3:27])[CH:25]=[N:24][CH:23]=3)[N:19]=[C:18]([CH3:28])[CH:17]=2)[C@H:13]([C:29]([O-:31])=[O:30])[CH2:12]1)(=[O:9])=[O:10].[Li+:34]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66772677HCID 66772677, compound

Product 1

HCID 66771983HCID 66771983, compound

Procedure

In analogy to the procedure described in example 253e, (2S,4R)-methyl 4-(2-chlorophenylsulfonyl)-1-(3-methyl-1-((1-methyl-1H-imidazol-5-yl)methyl)-1H-pyrazol-5-yl)pyrrolidine-2-carboxylate was saponified in the presence of lithium hydroxide to give the title compound as brown solid which was used in the next step without further purification. MS (ESI): m/z=462.1 [M−H]−.

Sources & evidence

ORD record: ord-b8827d90aa334702bbec9cc9b7b5e75e
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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