Isobutyl chloroformate → (S)-isobutyl 2-(4-(3-ethylureido)phenyl)-4-(3-methylmorpholino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

HRID 1697920Notes

Reaction equation

HRID 1697920 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][NH:21][CH2:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)=[O:5])[CH3:2].Cl[C:31]([O:33][CH2:34][CH:35]([CH3:37])[CH3:36])=[O:32]>>[CH2:1]([NH:3][C:4](=[O:5])[NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([N:23]3[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]3[CH3:29])[C:16]3[CH2:22][N:21]([C:31]([O:33][CH2:34][CH:35]([CH3:37])[CH3:36])=[O:32])[CH2:20][CH2:19][C:17]=3[N:18]=2)=[CH:9][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 62365Isobutyl chloroformateHCID 46913569(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenyl)urea

Product 1

HCID 59239446(S)-isobutyl 2-(4-(3-ethylureido)phenyl)-4-(3-methylmorpholino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate

Procedure

Compound eu was prepared according to the procedure described in Example 5 by reacting (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenyl)urea with isobutyl chloroformate. LC-MS: m/z=+497 (M+H)+.

Workup

  1. customCompound eu was prepared

Sources & evidence

ORD record
ord-54b935d05a3c4038a40ada701ddc158c
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

Loading…