Hydrochloric Acid → HCID 59239540, compound

HRID 1697941Notes

Reaction equation

HRID 1697941 reaction equation
CC1(C)[O:6][C@H:5]([CH2:7][N:8]2[CH2:17][CH2:16][C:15]3[C:14]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][C@@H:19]4[CH3:24])=[N:13][C:12]([C:25]4[CH:30]=[CH:29][C:28]([NH:31][C:32]([NH:34][CH2:35][CH3:36])=[O:33])=[CH:27][CH:26]=4)=[N:11][C:10]=3[CH2:9]2)[CH2:4][O:3]1.Cl>O>[OH:6][C@@H:5]([CH2:4][OH:3])[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:14]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][C@@H:19]3[CH3:24])=[N:13][C:12]([C:25]3[CH:30]=[CH:29][C:28]([NH:31][C:32]([NH:34][CH2:35][CH3:36])=[O:33])=[CH:27][CH:26]=3)=[N:11][C:10]=2[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59239258HCID 59239258, compound

Product 1

HCID 59239540HCID 59239540, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1-(4-(7-(((R)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-4-((S)-3-methylmorpholino)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea (jz) (50 mg, 0.10 mmol), 1 N HCl (0.20 mL, 0.2 mmol) and water (0.5 mL) was maintained at rt for 24 h. The mixture was purified by RPHPLC to afford 28 mg (60%) of the title compound ka as a colorless solid: LC-MS: m/z=+471 (M+H)+.

Workup

  1. customThe mixture was purified by RPHPLC

Sources & evidence

ORD record
ord-3a1edc6c1f534d71ab0e7f5d1e2abde0
Source dataset
uspto-grants-2012_04
Patent number
US08163763B2

Reaction notes

Loading…