Hydrochloric Acid → HCID 66727315, compound

HRID 1698217Notes

Reaction equation

HRID 1698217 reaction equation
[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH:10]S(C(C)(C)C)=O)[CH2:8][CH3:9])[O:4][N:3]=1.[ClH:17].O1CCOCC1>CO>[ClH:17].[Br:1][C:2]1[CH:6]=[C:5]([C@@H:7]([NH2:10])[CH2:8][CH3:9])[O:4][N:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727467HCID 66727467, compound

Product 1

HCID 66727315HCID 66727315, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(3-bromo-isoxazol-5-yl)-propyl]amide (17.5 mg, 0.0566 mmol) in MeOH (1 mL) was added a 4 M solution of HCl in dioxane (0.70 mL, 0.28 mmol) dropwise. After 2.5 hours, the mixture was concentrated in vacuo to afford the title compound which was used with out purification. MS m/z 188.24 (M−53), 190.20 (M+2−53).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-7deac49ed5c247e4be942cd0d0edd503
Source dataset
uspto-grants-2012_04
Patent number
US08163918B2

Reaction notes

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