1-Bromo-2-methylpropane → HCID 67276389, compound

HRID 1698397Notes

Reaction equation

HRID 1698397 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH2:10])=[C:4]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:3]=1.[H-].[Na+].Br[CH2:18][CH:19]([CH3:21])[CH3:20]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][NH:10][CH2:18][CH:19]([CH3:21])[CH3:20])=[C:4]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:3]=1

Participants

4

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 24758Sodium hydrideHCID 66671971HCID 66671971, compound

Product 1

HCID 67276389HCID 67276389, compoundYield 30%

Procedure

In a manner analogous to example 1 c, the process is carried out by a reaction of 4 g (16 mmol) of (4-bromo-2-tert-butylphenyl)ethylamine (example 1b) with 1.4 g (34 mmol) of 60% sodium hydride and with 3.7 ml (34 mmol) of 1-bromo-2-methylpropane. 1.5 g of (4-bromo-2-tert-butylphenyl)ethylisobutylamine are obtained in the form of an oil (yield=30%).

Sources & evidence

ORD record
ord-7747337ac40544be8b6dba637e52f9e9
Source dataset
uspto-grants-2012_04
Patent number
US08163952B2

Reaction notes

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