Dichloromethane → Tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate

HRID 169848Notes

Reaction equation

HRID 169848 reaction equation
[Br:6][CH2:7][c:8]1[c:9]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[n:10][c:11](-[c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[s:12]1.[CH2:1]1[CH2:2][CH2:3][NH:4][CH2:5]1.[CH:26]([N:27]([CH:28]([CH3:29])[CH3:30])[CH2:31][CH3:32])([CH3:33])[CH3:34].[Cl:35][CH2:36][Cl:37]>>[CH2:1]1[CH2:2][CH2:3][N:4]([CH2:7][c:8]2[c:9]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[n:10][c:11](-[c:13]3[cH:14][cH:15][cH:16][cH:17][cH:18]3)[s:12]2)[CH2:5]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 31268PyrrolidineHCID 81531DiisopropylethylamineHCID 67424804Tert-butyl 5-(bromomethyl)-2-phenylthiazole-4-carboxylate

Product 1

HCID 67425601Tert-butyl 2-phenyl-5-(pyrrolidin-1-ylmethyl)thiazole-4-carboxylate

Sources & evidence

ORD record
ord-fe28084f547844c688b711763504f936
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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