反应详情

温度

50 °C

1-Bromo-4-(ethylthio)benzene (0.5 g, 2.3 mmol) was added to a stirred mixture of magnesium turnings (1.96 g, 82 mmol) in THF (10 mL). 1,2-Dibromoethane (30 μL) was then added and the mixture was heated at reflux to initiate the reaction. A solution of 1-bromo-4-(ethylthio)benzene (18.2 g, 84 mmol) in THF (60 mL) was added at such a rate to maintain the reaction mixture at gentle reflux. The reaction mixture was then stirred at 50° C. for 90 min and cooled to ambient temp to give a 1.16M solution of 4-(ethylthio)phenylmagnesium bromide in THF which was used in the next reaction.

1. temperaturethe mixture was heated
2. temperatureat reflux
3. customthe reaction
4. temperatureto maintain the reaction mixture at gentle reflux
5. temperaturecooled to ambient temp