反应详情

To a solution of 50 g of 5-bromo-2-hydroxy-3-methoxybenzaldehyde in 200 ml of an ethanol:THF=1:1 mixed solvent there was added 16.4 g of sodium borohydride while cooling on ice. After stirring at room temperature for 2 hours, 1N hydrochloric acid was added to the reaction mixture while cooling on ice. The organic layer was washed with ethyl acetate and dried over anhydrous magnesium sulfate. The desiccating agent was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (50 g) as a crude product.

1. temperaturewhile cooling on ice
2. temperaturewhile cooling on ice
3. washThe organic layer was washed with ethyl acetate
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationThe desiccating agent was filtered off
6. concentrationthe filtrate was concentrated under reduced pressure