Tri-o-tolylphosphine → HCID 18551163, compound

HRID 1698811Notes

Reaction equation

HRID 1698811 reaction equation
C([O:3][C:4](=[O:22])[C:5]([OH:21])([C:17]([F:20])([F:19])[F:18])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][CH:11]=1)([CH3:9])[CH3:8])C.C([Sn](CCCC)(CCCC)[C:28]([O:30]CC)=[CH2:29])CCC.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C>CN(C)C=O>[C:28]([C:13]1[CH:12]=[CH:11][C:10]([C:7]([CH3:9])([CH3:8])[CH2:6][C:5]([OH:21])([C:17]([F:20])([F:18])[F:19])[C:4]([OH:3])=[O:22])=[CH:15][CH:14]=1)(=[O:30])[CH3:29]

Participants

5

Reactant 3

HCID 80271Tri-o-tolylphosphineHCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 17935607HCID 17935607, compound

Product 1

HCID 18551163HCID 18551163, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Analogously to the compound above of 4-(4-bromophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, tributyl-1-ethoxyvinyltin, tri-o-tolylphosphine and bis-tri-o-tolylphosphine-palladium(II) chloride in dimethylformamide to 120° C. and subsequent acidic hydrolysis of the enol ether and alkaline saponification, melting point 158-162° C.

Sources & evidence

ORD record
ord-ff647cfa10e9428b819b76620ec29d8b
Source dataset
uspto-grants-2002_02
Patent number
US06344454B1

Reaction notes

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