Dimethylformamide → HCID 18551156, compound

HRID 1698813Notes

Reaction equation

HRID 1698813 reaction equation
C([O:3][C:4](=[O:22])[C:5]([OH:21])([C:17]([F:20])([F:19])[F:18])[CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13](Br)=[CH:12][CH:11]=1)([CH3:9])[CH3:8])C.[CH3:23][N:24](C)C=O>[C-]#N.[Zn+2].[C-]#N>[C:23]([C:13]1[CH:14]=[CH:15][C:10]([C:7]([CH3:8])([CH3:9])[CH2:6][C:5]([OH:21])([C:17]([F:18])([F:19])[F:20])[C:4]([OH:3])=[O:22])=[CH:11][CH:12]=1)#[N:24]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 17935607HCID 17935607, compound

Product 1

HCID 18551156HCID 18551156, compound

Reagents, catalysts & solvents 1

HCID 11186Zinc cyanide (Zn(CN)2)Catalyst

Procedure

From 4-(4-bromophenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeric acid ethyl ester, zinc cyanide and tetrakis-triphenylphosphine-palladium in dimethylformamide at 140° C. After saponification, the title acid is obtained as a foam.

Workup

  1. customat 140° C

Sources & evidence

ORD record
ord-072a84b74ff24739b0050301c3f76e00
Source dataset
uspto-grants-2002_02
Patent number
US06344454B1

Reaction notes

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