Triethylamine → HCID 70120094, compound

HRID 1698866Notes

Reaction equation

HRID 1698866 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH2:13][CH2:14][CH3:15])[C:10]([NH2:12])=[S:11].C(N(CC)CC)C.Br[CH:24]([CH3:35])[C:25]([C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][C:28]=1[Cl:34])=O>C(O)C>[Cl:34][C:28]1[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:27]=1[C:25]1[N:12]=[C:10]([N:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[Cl:1])[CH2:13][CH2:14][CH3:15])[S:11][C:24]=1[CH3:35]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 109239912-Bromo-1-(2,4-dichlorophenyl)propan-1-one2×HCID 18322259HCID 18322259, compound2×

Product 1

HCID 70120094HCID 70120094, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
78 °C

Procedure

To 1.07 g of N-(2,4-dichlorophenyl)-N-propylthiourea (Compound 10-1) in 6 ml of ethanol, there is added 1 ml of triethylamine followed, dropwise, by 1.3 g of 2-bromo-1-(2,4-dichlorophenyl)propan-1-one (Compound 1-1). The reaction mixture is heated for 3 hours at 78° C., it is evaporated to dryness and then the residue is taken up in dichloromethane. The organic phase is washed with water, dried over sodium sulphate and evaporated to dryness under vacuum.

Workup

  1. customit is evaporated to dryness
  2. washThe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. customevaporated to dryness under vacuum

Sources & evidence

ORD record
ord-9b2f018716ad476187c7eb54abe2abd7
Source dataset
uspto-grants-2002_02
Patent number
US06344470B1

Reaction notes

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