Isobutyronitrile → 5-chloro-2,2-dimethylpentanenitrile

HRID 1699119Notes

Reaction equation

[C:1](#[N:5])[CH:2]([CH3:4])[CH3:3].Br[CH2:7][CH2:8][CH2:9][Cl:10]>>[Cl:10][CH2:9][CH2:8][CH2:7][C:2]([CH3:4])([CH3:3])[C:1]#[N:5]

Participants

Reactant 2

HCID 6559Isobutyronitrile

HCID 80061-Bromo-3-chloropropane

Product 1

HCID 2642175-chloro-2,2-dimethylpentanenitrile

Procedure

reacting isobutyronitrile with 1-bromo-3-chloropropane in the presence of a first base in a non-polar solvent at a temperature of about 15°to 65°C. to afford 5-chloro-2,2-dimethylpentanenitrile;

Workup

customof about 15°to 65°C.

Sources & evidence

ORD record: ord-78beef2858274801a207cbab4e15eac3
Source dataset: uspto-grants-2002_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06344580B1

Reaction notes

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