Hydrochloric Acid → HCID 18321245, compound

HRID 1699242Notes

Reaction equation

HRID 1699242 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:8](=[O:17])[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:3][CH:2]=1.C(O)C.[ClH:21]>[Pt](=O)=O>[ClH:21].[NH:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:17])[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 18321205HCID 18321205, compound

Product 1

HCID 18321245HCID 18321245, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

A mixture of 1.1 g (4.949 mmol) of 3-(4-pyridinyl)-2(1H)-quinolone (D. R. Bragg and D. G. Wibberley, J. Chem. Soc. 1961, 5074-5077), 100 ml of ethanol, 5 ml (5 mmol) of iN hydrochloric acid and 0.2 g platinum (IV) oxide was hydrogenated for 4 hours at room temperature. The catalyst was filtered off, the filtrate evaporated down in vacuo and the residue was triturated with isopropanol. The precipitated crystals were suction filtered, washed with isopropanol and diethylether and dried in vacuo. Yield: 0.64 g (56.2% of theory).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated down in vacuo
  3. customthe residue was triturated with isopropanol
  4. filtrationfiltered
  5. washwashed with isopropanol and diethylether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-8272e23ad47e4537a50255f1354605b3
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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