HCID 18321485, compound → tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate

HRID 1699257Notes

Reaction equation

HRID 1699257 reaction equation
[CH3:1][C:2]([CH3:26])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:18][CH2:17][N:16](CC3C=CC=CC=3)[CH2:15][CH2:14]2)[CH2:9][CH2:8]1)=[O:6])[CH3:3]>[OH-].[OH-].[Pd+2]>[CH3:3][C:2]([CH3:26])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH2:9][CH2:8]1)=[O:6])[CH3:1]

Participants

3

Reactant 1

HCID 18321485HCID 18321485, compound

Product 1

HCID 17750356tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylateYield 79.7%

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

Prepared analogously to Example A3f) from 1-(1,1-dimethylethoxycarbonyl)-4-[1-(phenylmethyl)-4-piperidinyl]piperazine by hydrogenolysis, but using Pearlman's catalyst instead of palladium/charcoal, in a yield of 79.7% of theory.

Sources & evidence

ORD record
ord-e521d7ae37144e2fa700680197cbf078
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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