Trifluoroacetic acid → HCID 18321323, compound

HRID 1699279Notes

Reaction equation

HRID 1699279 reaction equation
[CH2:1]([O:3][C:4]([C:6]([C:26]([O:28][CH2:29][CH3:30])=[O:27])([CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]([CH3:25])[CH:17]=1)[CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])=[O:5])[CH3:2].FC(F)(F)C(O)=O.C(OC(C)C)(C)C>ClCCl>[CH2:1]([O:3][C:4]([C:6]([C:26]([O:28][CH2:29][CH3:30])=[O:27])([CH2:15][C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]([CH3:25])[CH:17]=1)[CH2:7][C:8]([OH:10])=[O:9])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7914Diisopropyl EtherHCID 18321008HCID 18321008, compound

Product 1

HCID 18321323HCID 18321323, compoundYield 63.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Produced analogously to Example A1b) from tert.-butyl β,β-bis(ethoxycarbonyl)-1-methyl-1H-indol-3-butanoate through the action of trifluoroacetic acid in dichloromethane in a yield of 63.5% of theory. Colourless crystals of Mp. 127-130° C. (diisopropylether).

Sources & evidence

ORD record
ord-fb59eae6d814491bb5c4893c7e08e8b9
Source dataset
uspto-grants-2002_02
Patent number
US06344449B1

Reaction notes

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