Methanesulfonic Acid → HCID 178477268, compound

HRID 1699403Notes

Reaction equation

HRID 1699403 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].C[S:7][CH2:8][C:9]1[C:19]2[O:18][CH2:17][CH2:16][C:15]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])=[CH:14][C:13]=2[CH:12]=[CH:11][CH:10]=1.[CH:26](OC(C)C)(C)C>CO>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[CH3:26][C:8]([C:9]1[C:19]2[O:18][CH2:17][CH2:16][C:15]([C:20]([NH:22][C:23]([NH2:25])=[NH:24])=[O:21])=[CH:14][C:13]=2[CH:12]=[CH:11][CH:10]=1)=[S:7]

Participants

5

Reactant 3

HCID 6395Methanesulfonic AcidHCID 7914Diisopropyl EtherHCID 178503654HCID 178503654, compound

Product 1

HCID 178477268HCID 178477268, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methanesulfonic acid (0.04 ml) was added to the mixture of (2,3-dihydro-9-methylthiomethyl-1-benzoxepin-4-carbonyl)guanidine (0.15 g) in methanol (1.5 ml) and the mixture was stirred at ambient temperature for 30 minutes. To the mixture was added diisopropyl ether (3 ml). The isolated crystalline was collected by filtration and recrystallized from a mixture of methanol and diisopropyl ether to give (2,3-dihydro-9-methylthiocarbonyl-1-benzoxepin-4-carbonyl)guanidine methanesulfonate (0.12 g).

Workup

  1. filtrationThe isolated crystalline was collected by filtration
  2. customrecrystallized from a mixture of methanol and diisopropyl ether

Sources & evidence

ORD record
ord-4440015a105045ff8eeb055351f36e0a
Source dataset
uspto-grants-2002_02
Patent number
US06346527B1

Reaction notes

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