反应详情

14.7 g (0.1 mol) of 5-aminotetralin were refluxed with 18 g (0.11 mol) of bis(β-chloroethyl)amine hydrochloride in 300 ml of n-butanol for 48 h and, after cooling, 5.4 g of sodium carbonate were added and the mixture was refluxed for a further 20 h. The precipitate which formed on cooling was filtered off with suction and taken up in water, and 2N sodium hydroxide solution was added. The aqueous phase was extracted with ethyl acetate, and washing with water and drying over sodium sulfate were followed by evaporation under reduced pressure. It was possible in this way to isolate 10.7 g (50%) of the product as an oil.

1. temperatureafter cooling
2. temperaturethe mixture was refluxed for a further 20 h
3. customThe precipitate which formed
4. temperatureon cooling
5. filtrationwas filtered off with suction
6. addition2N sodium hydroxide solution was added
7. extractionThe aqueous phase was extracted with ethyl acetate
8. washwashing with water
9. dry with materialdrying over sodium sulfate
10. customwere followed by evaporation under reduced pressure