反应详情

30.0 g of N-(p-toluenesulfonyl)-alanine and 6 to 7 drops of DMF (dimethylformamide) were dissolved in 100 ml of dichloromethane and 5 ml of oxalyl chloride was added dropwise. After stirring for 3 hours at room temperature the reaction mixture was evaporated down to a residue which was dissolved in 100 ml of dichloromethane. The dichloromethane was again evaporated and the resulting residue dissolved in 50 ml of dichloromethane followed by the addition of 100 ml hexane. After standing in the refrigerator overnight the crystals, so formed, were filtered and dried.

1. customwas evaporated down to a residue which
2. dissolutionwas dissolved in 100 ml of dichloromethane
3. customThe dichloromethane was again evaporated
4. dissolutionthe resulting residue dissolved in 50 ml of dichloromethane
5. additionfollowed by the addition of 100 ml hexane
6. customAfter standing in the refrigerator overnight
7. customso formed
8. filtrationwere filtered
9. customdried