Potassium Carbonate → HCID 18318196, compound

HRID 1700291Notes

Reaction equation

HRID 1700291 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21]C(C(F)(F)F)=O)=[CH:17][C:16]=2[N+:28]([O-:30])=[O:29])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O-])([O-])=O.[K+].[K+]>CO.O>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][C:16]=2[N+:28]([O-:30])=[O:29])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 18318231HCID 18318231, compound

Product 1

HCID 18318196HCID 18318196, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

To 4-(N′-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-nitro-N-(trifluoromethylcarbonyl)benzenamine in methanol (150 mL) and water (150 mL) was added K2CO3 (6.0 g) and the reaction was heated to 50° C. for overnight. The reaction was extracted with ethyl acetate. The extract was dried, concentrated and purified on silica gel column (ethyl acetate/hexane) to afford 4-(N′-(t-butoxycarbonyl)piperidin-4-yl)oxy-3-nitrobenzenamine (11.0 g).

Workup

  1. extractionThe reaction was extracted with ethyl acetate
  2. customThe extract was dried
  3. concentrationconcentrated
  4. custompurified on silica gel column (ethyl acetate/hexane)

Sources & evidence

ORD record
ord-97e23f9994ff4cdabd4d85ccb9feb91e
Source dataset
uspto-grants-2002_02
Patent number
US06350761B1

Reaction notes

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