Triethylamine → HCID 53935748, compound

HRID 1700330Notes

Reaction equation

HRID 1700330 reaction equation
[CH2:1]([NH2:10])[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:11]=[C:12]1[O:16][C:14](=[O:15])[CH2:13]1.C(N(CC)CC)C.C(=O)([O-])O.[Na+]>C1(C)C=CC=CC=1>[O:16]=[C:12]([CH3:11])[CH2:13][C:14]([NH:10][CH2:1][CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:15]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 12661DiketeneHCID 203693-Phenylprop-2-en-1-amineHCID 516892Sodium Bicarbonate

Product 1

HCID 53935748HCID 53935748, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3.06 g (23.0 mmol) of cinnamylamine, 2.32 ml (30.1 mmol) of ketene dimer and 0.321 ml (2.30 mmol) of triethylamine were heated at 70° C. under stirring in 23 ml of toluene for 3 hours. A saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture. After the extraction with ethyl acetate, the organic layer was dried over anhydrous sodium sulfate and then concentrated under reduced pressure to obtain the title compound.

Workup

  1. extractionAfter the extraction with ethyl acetate
  2. dry with materialthe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-1f998c9b97374f0793145cbd48e8cff6
Source dataset
uspto-grants-2002_02
Patent number
US06350762B1

Reaction notes

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