HCID 131723123, compound → HCID 18317858, compound

HRID 1700378Notes

Reaction equation

HRID 1700378 reaction equation
[CH2:1]([O:8][C:9]([NH:11][C:12]1([C:16]2(C(OC(C)(C)C)=O)[C:28]3[NH:27][C:26]4[C:21](=[CH:22][C:23]([CH3:29])=[CH:24][CH:25]=4)[C:20]=3[CH2:19][CH2:18][NH:17]2)[CH2:15][CH2:14][CH2:13]1)=[O:10])[C:2]1C=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.Cl>[CH3:29][C:23]1[CH:22]=[C:21]2[C:26](=[CH:25][CH:24]=1)[NH:27][C:28]1[CH:16]([C:12]3([NH:11][C:9](=[O:10])[O:8][C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)[CH2:13][CH2:14][CH2:15]3)[NH:17][CH2:18][CH2:19][C:20]2=1

Participants

4

Reactant 1

HCID 131723123HCID 131723123, compound

Product 1

HCID 18317858HCID 18317858, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

0.9 g of the compound obtained in Example 97 are dissolved in 50 ml of ethyl acetate into which gaseous hydrogen chloride is bubbled. After reaction for one hour, the precipitate formed is filtered off, washed with diethyl ether and dried, enabling the expected product to be isolated.

Workup

  1. customis bubbled
  2. customAfter reaction for one hour
  3. customthe precipitate formed
  4. filtrationis filtered off
  5. washwashed with diethyl ether
  6. customdried
  7. customto be isolated

Sources & evidence

ORD record
ord-32eb5cfbec5b45b88aa54e7c582e70c0
Source dataset
uspto-grants-2002_02
Patent number
US06350757B1

Reaction notes

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