Hydrochloric Acid → HCID 178424165, compound

HRID 1700609Notes

Reaction equation

HRID 1700609 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[C:8]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[CH3:18])=[CH:9][C:10](=O)[C:3]=12.[C:19]([NH:22][NH2:23])([NH2:21])=[NH:20].[ClH:24].Cl>C(O)C>[ClH:24].[NH:22]([N:23]=[C:10]1[C:3]2[C:4](=[N:5][CH:6]=[CH:7][C:2]=2[CH3:1])[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[CH:9]1)[C:19]([NH2:21])=[NH:20]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 183172974-Methyl-7-(2-methylphenyl)-5-oxo-cyclopenta[2,1-b]pyridineHCID 178418668HCID 178418668, compound

Product 1

HCID 178424165HCID 178424165, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-methyl-7-(2-methylphenyl)-5-oxo-cyclopenta[2,1-b]pyridine (48 mg), aminoguanidine hydrochloride (25 mg) and concentrated hydrochloric acid (40 mg) in ethanol (1 ml) was refluxed for 2 hours. The reaction solution was cooled, and precipitated crystals were filtered, washed with ethanol and dried to give 5-guanidinoimino-4-methyl-7-(2-methylphenyl)cyclopenta[2,1-b]pyridine hydrochloride (Compound 91) (48 mg) as yellow crystals.

Workup

  1. temperaturewas refluxed for 2 hours
  2. temperatureThe reaction solution was cooled
  3. customprecipitated crystals
  4. filtrationwere filtered
  5. washwashed with ethanol
  6. customdried

Sources & evidence

ORD record
ord-48ef27a0bc3d405cb74fed725068992e
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

Loading…