HCID 11109189, compound → HCID 11065720, compound

HRID 1700628Notes

Reaction equation

HRID 1700628 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[CH:11]=[C:10]([S:15][CH2:16][C:17](=O)[CH3:18])[CH2:9]1>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][C:12](=[O:14])[C:11]2[C:17]([CH3:18])=[CH:16][S:15][C:10]=2[CH2:9]1

Participants

3

Reactant 1

HCID 11109189HCID 11109189, compound

Product 1

HCID 11065720HCID 11065720, compoundYield 7.5%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 5-(2-chlorophenyl)-3-(2-oxopropylthio)-2-cyclohexen-1-one (1.0 g) in xylene (10 ml) was refluxed for 7.5 days and cooled, and the reaction solution was purified with silica gel column chromatography (EtOAc/hexane) to give oil of 6-(2-chlorophenyl)-3-methyl-4,5,6,7-tetrahydrobenzothiophene-4-one (0.07 g).

Workup

  1. temperaturecooled
  2. customthe reaction solution was purified with silica gel column chromatography (EtOAc/hexane)

Sources & evidence

ORD record
ord-4e522adf603a4af88e33087f0c6a68c1
Source dataset
uspto-grants-2002_02
Patent number
US06350749B1

Reaction notes

Loading…