反应详情

To a solution of 1-amino-5-(2-chlorophenyl)cyclohexen-3-one (2.0 g) in acetonitrile (50 ml) was added phenyl isothiocyanate (1.2 g), and the mixture was refluxed for 15 hours. Under reduced pressure, the solvent was evaporated, and to the residue were added ethanol (20 ml) and hydrazine hydrate (0.55 g). The mixture was refluxed for 1 hour, and under reduced pressure, the solvent was evaporated. The residue was washed with ethyl acetate to give yellow crystals of 6-(2-chlorophenyl)-3-phenylamino-4,5,6,7-tetrahydroindazol-4-one (0.8 g).

1. temperaturethe mixture was refluxed for 15 hours
2. customUnder reduced pressure, the solvent was evaporated
3. additionto the residue were added ethanol (20 ml) and hydrazine hydrate (0.55 g)
4. temperatureThe mixture was refluxed for 1 hour
5. customunder reduced pressure, the solvent was evaporated
6. washThe residue was washed with ethyl acetate