Hydrazine hydrate (1:1) → HCID 18318530, compound

HRID 1700776Notes

Reaction equation

HRID 1700776 reaction equation
C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:36]=[CH:35][C:10]([CH2:11][C:12]2[C:13]3[CH:34]=[CH:33][CH:32]=[CH:31][C:14]=3[S:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[CH:19][CH:18]=2)=[CH:9][CH:8]=1)C.O.[NH2:39][NH2:40]>CCO>[NH:39]([C:4](=[O:3])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][C:12]2[C:13]3[CH:34]=[CH:33][CH:32]=[CH:31][C:14]=3[S:15][C:16]=2[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][CH2:25][N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)=[CH:19][CH:18]=2)=[CH:35][CH:36]=1)[NH2:40]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18318442HCID 18318442, compound

Product 1

HCID 18318530HCID 18318530, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 3-[4-(2-ethoxy-2-oxoethoxy)benzyl]-2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophene (400 mg), hydrazine hydrate (2 mL), and EtOH (50 mL was refluxed for 3.5 hours, cooled, and evaporated in vacuo to give the title compound as an amorphous solid (0.4 g, 100%).

Workup

  1. temperaturewas refluxed for 3.5 hours
  2. temperaturecooled
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-1628ad441dd342eca122ca4d7759728d
Source dataset
uspto-grants-2002_02
Patent number
US06350774B1

Reaction notes

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