Hydrochloric Acid → 1-(3-Methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride

HRID 1701014Notes

Reaction equation

HRID 1701014 reaction equation
C(OC(=O)[NH:7][CH:8]([C:16]1[O:20][N:19]=[C:18]([CH3:21])[N:17]=1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.[ClH:23]>C(OCC)(=O)C>[ClH:23].[CH3:21][C:18]1[N:17]=[C:16]([CH:8]([NH2:7])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[O:20][N:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22949409N-tert-butoxycarbonyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenylethylamine

Product 1

HCID 225924571-(3-Methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethyl]carbamic acid tertbutyl ester (2.4 g, 7.9 mmol) was dissolved in a saturated solution of hydrogen chloride in ethyl acetate (40 ml). After 5 h at 20° C. the reaction mixture was concentrated in vacuo. The residue was crystallized from ethyl acetate to give 2.05 g of (R) 1-(3-methyl-[1,2,4]oxadiazol-5-yl)-2-phenylethylamine hydrochloride.

Workup

  1. concentrationAfter 5 h at 20° C. the reaction mixture was concentrated in vacuo
  2. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-3874dcf9002646f6aaf2b4a01894aee5
Source dataset
uspto-grants-2002_02
Patent number
US06350767B1

Reaction notes

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