1,2-Dichloroethane → (RS)-N-(4-cyano-benzyl)-2-[2,6-difluoro-3-(4-fluoro-phenoxy)-phenyl]-2-methoxy-acetamide

HRID 170156Notes

Reaction equation

HRID 170156 reaction equation
[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][C:9]([CH:10]([O:11][CH3:12])[c:13]2[c:14]([F:21])[c:15]([OH:20])[cH:16][cH:17][c:18]2[F:19])=[O:22])[cH:23][cH:24]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:42][CH2:43][CH2:44][Cl:45].[OH:25][C:26](=[O:27])[c:28]1[cH:29][cH:30][c:31]([F:32])[cH:33][cH:34]1>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([CH2:7][NH:8][C:9]([CH:10]([O:11][CH3:12])[c:13]2[c:14]([F:21])[c:15]([O:20][c:28]3[cH:29][cH:30][c:31]([F:32])[cH:33][cH:34]3)[cH:16][cH:17][c:18]2[F:19])=[O:22])[cH:23][cH:24]1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 8471TriethylamineHCID 99734-Fluorobenzoic AcidHCID 21905078(RS)-N-(4-Cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-methoxy-acetamide

Product 1

HCID 21905328(RS)-N-(4-cyano-benzyl)-2-[2,6-difluoro-3-(4-fluoro-phenoxy)-phenyl]-2-methoxy-acetamide

Sources & evidence

ORD record
ord-f17d6fede9904374baf7fca1b7c03294
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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