Hydrochloric Acid → HCID 20346954, compound

HRID 1701562Notes

Reaction equation

HRID 1701562 reaction equation
[CH:1]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]([CH2:13][CH3:14])[CH3:12])[C:6]=1[N:15]=[C:16]=[S:17])([CH2:3][CH3:4])[CH3:2].[CH:18]([NH2:21])([CH3:20])[CH3:19].Cl>>[CH:11]([C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([CH:1]([CH2:3][CH3:4])[CH3:2])[C:6]=1[NH:15][C:16]([NH:21][CH:18]([CH3:20])[CH3:19])=[S:17])([CH2:13][CH3:14])[CH3:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6363IsopropylamineHCID 20346983HCID 20346983, compound

Product 1

HCID 20346954HCID 20346954, compound

Procedure

15.0 g of 2,6-di-sec.-butyl-phenyl isothiocyanate are introduced, whilst cooling, into 20 g of a 65% strength aqueous solution of isopropylamine. After stirring for 3 hours at 20°, the batch is stirred into dilute hydrochloric acid, the reaction product which has precipitated in a crystalline form is filtered off and washed until neutral, and the paste is triturated with 50% strength methanol, again filtered off and dried.

Workup

  1. customthe reaction product which has precipitated in a crystalline form
  2. filtrationis filtered off
  3. washwashed until neutral, and the paste
  4. customis triturated with 50% strength methanol
  5. filtrationagain filtered off
  6. customdried

Sources & evidence

ORD record
ord-871b7eec5df345fb9c61a842917b3287
Source dataset
uspto-grants-1980_03
Patent number
US04194008

Reaction notes

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