Hydrochloric Acid → HCID 20347056, compound

HRID 1701568Notes

Reaction equation

HRID 1701568 reaction equation
[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:7]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH:17]([CH2:19][CH3:20])[CH3:18])[C:12]=1[N:21]=[C:22]=[S:23])([CH2:9][CH3:10])[CH3:8].Cl>>[CH:17]([C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH:7]([CH2:9][CH3:10])[CH3:8])[C:12]=1[NH:21][C:22]([NH:6][CH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[S:23])([CH2:19][CH3:20])[CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2906CyclopentylamineHCID 20346983HCID 20346983, compound

Product 1

HCID 20347056HCID 20347056, compound

Procedure

20.0 g of cyclopentylamine are taken and 15.0 g of 2,6-di-sec.-butyl-phenyl isothiocyanate are introduced whilst stirring. The reaction takes place exothermically. The batch is left to stand for 12 hours and is then stirred with dilute hydrochloric acid and filtered. The filter cake is triturated with dilute methanol, filtered off, washed and dried. For further purification, the product can be recrystallised from petroleum ether. Yield 18 g; melting point 107°-108° C.

Workup

  1. waitThe batch is left
  2. filtrationfiltered
  3. customThe filter cake is triturated with dilute methanol
  4. filtrationfiltered off
  5. washwashed
  6. customdried
  7. customFor further purification
  8. customthe product can be recrystallised from petroleum ether

Sources & evidence

ORD record
ord-186bb0ada3f34809b9abfad28bf6fc4b
Source dataset
uspto-grants-1980_03
Patent number
US04194008

Reaction notes

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