反应详情

To a stirred solution of 563 mg (1 mmol) of benzhydryl 2-(3-phenoxyacetamido-2-oxoazetidin-1-yl)-3-methyl-4-bromo-2-butenoate in a mixture of 2 ml propylene oxide and 4 ml of dimethylformamide at 0° was added 128 mg (1.1 mmol) of 1-methyl-5-mercapto-1,2,3,4-tetrazole. After 1 hour at 0°, the solution was added to a large amount of ethyl acetate and washed thoroughly with brine. The ethyl acetate layer was dried and evaporated to provide the title product: nmr (CDCl3) δ 2.20 and 2.37 (s, 3, CH3), 3.83 and 3.86 (s, 3, N--CH3), 4.43 (s, 2, --CH2S--), 5.88 (d, 2, C4 --H), 5.50 (q, 1, C3 --H), 4.57 (s, 2, side chain CH2) and 7.2 (b, ArH).

1. washwashed thoroughly with brine
2. dry with materialThe ethyl acetate layer was dried
3. customevaporated