2-Fluorobenzoyl chloride → HCID 70586839, compound

HRID 1701804Notes

Reaction equation

HRID 1701804 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S:11]1([C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:15](=[O:16])[NH:14]1)(=[O:13])=[O:12].[Na]>O1CCCC1>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:14]1[C:15](=[O:16])[C:17]2[C:22](=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:11]1(=[O:13])=[O:12])=[O:5]

Participants

4

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 24181110Benzosulfinide sodium; Garantose sodium

Product 1

HCID 70586839HCID 70586839, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-fluorobenzoyl chloride, from example 4A, above, and 18.5 g (0.09 mole) of sodium saccharin is refluxed in 100 ml of tetrahydrofuran (THF) overnight. The reaction mixture is filtered hot, and the filtrate is concentrated to a partial solid/oil. The product is triturated with ether and air dried to yield 10.3 g of 2-(2-fluorobenzoyl)saccharin, m.p. 148°-151° C.

Workup

  1. filtrationThe reaction mixture is filtered hot
  2. concentrationthe filtrate is concentrated to a partial solid/oil
  3. customThe product is triturated with ether and air
  4. customdried

Sources & evidence

ORD record
ord-813bf34d8d784c4fb012699e24343756
Source dataset
uspto-grants-1980_03
Patent number
US04195023

Reaction notes

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