Ammonium Hydroxide → HCID 12953404, compound

HRID 1701940Notes

Reaction equation

HRID 1701940 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][C:14]([O:16]CC)=O)[N:12]=2)[CH:5]=[CH:6][CH:7]=1.O1CCOCC1.[NH4+:25].[OH-]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][C:14]([NH2:25])=[O:16])[N:12]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 312751,4-DioxaneHCID 12953392HCID 12953392, compound

Product 1

HCID 12953404HCID 12953404, compound

Procedure

Ethyl 2-(3-bromophenyl)-4-thiazolylacetate prepared by the process in Example 2 (10 g) in 75 ml of 28% NH4OH was stirred at room temperature. About 10 ml of dioxane was added to facilitate mixing. After 10 days, the crystalline product was filtered. The yield of product was 8.3 g, mp 150°-152° C. When recrystallized from alcohol, it melted 152°-154° C.

Workup

  1. additionto facilitate mixing
  2. filtrationthe crystalline product was filtered
  3. customWhen recrystallized from alcohol, it
  4. custommelted 152°-154° C.

Sources & evidence

ORD record
ord-d1921305343c483f85d27b7b67a0bc2e
Source dataset
uspto-grants-1983_04
Patent number
US04379791

Reaction notes

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