N-(3-Aminopropyl)morpholine → HCID 53688069, compound

HRID 1701977Notes

Reaction equation

HRID 1701977 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][CH:9]=O)[CH2:3][CH2:2]1.[NH2:11][CH2:12][CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>O1CCOCC1.[Ni]>[O:18]1[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][CH2:12][N:11]([CH2:9][CH2:8][CH2:7][N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH2:9][CH2:8][CH2:7][N:4]2[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)[CH2:16][CH2:17]1

Participants

5

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 111054823-Morpholinopropanal

Product 1

HCID 53688069HCID 53688069, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

143 g (1 mol) of 3-morpholinopropionaldehyde in 143 g of dioxane are pumped into 72 g (0.5 mol) of aminopropylmorpholine and 30 g of Raney nickel at 120° C. and hydrogenated at 180 bar.

Sources & evidence

ORD record
ord-81fdeffed5ed4be7a4a704a451bbe4bf
Source dataset
uspto-grants-1983_04
Patent number
US04379861

Reaction notes

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