反应详情

28 g of 2,4-dichlorobenzyl 3-pyridyl ketone are dissolved in 800 ml of dimethylformamide and treated portionwise at 0° with 5.5 g of sodium hydride (50% dispersion in oil). After 2 hours at room temperature, 14.9 g of methyl iodide are added and the mixture is stirred at room temperature for an additional 3 hours. Then the mixture is poured into water and extracted with diethyl ether, and the organic phase is washed and dried over anhydrous sodium sulfate and subsequently concentrated. The product is purified by chromatography on silica gel with n-hexane/ethyl acetate (1:2) to yield 2-(2,4-dichlorophenyl)-1-(3-pyridyl)-1-propanone as an oil.

1. extractionextracted with diethyl ether
2. washthe organic phase is washed
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationsubsequently concentrated
5. customThe product is purified by chromatography on silica gel with n-hexane/ethyl acetate (1:2)