Sodium hydride → 2,2-Dimethyl-4-(1,2,4-triazol-1-yl)-6-phenoxy-hexan-3-one

HRID 1702151Notes

Reaction equation

[H-].[Na+].[CH3:3][C:4]([CH3:14])([C:6](=[O:13])[CH2:7][N:8]1[CH:12]=[N:11][CH:10]=[N:9]1)[CH3:5].Br[CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH3:5][C:4]([CH3:14])([C:6](=[O:13])[CH:7]([N:8]1[CH:12]=[N:11][CH:10]=[N:9]1)[CH2:16][CH2:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:3]

Participants

Reactant 3

HCID 24758Sodium hydride

HCID 68526Benzene, (2-bromoethoxy)-

HCID 1008773,3-Dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone

Product 1

HCID 128066802,2-Dimethyl-4-(1,2,4-triazol-1-yl)-6-phenoxy-hexan-3-one

Procedure

2.6 g of sodium hydride, 16.7 g of 2,2-dimethyl-4-(1,2,4-triazol-1-yl)-butan-3-one and 20.1 g of 1-bromo-2-phenoxyethane are reacted by a method similar to that of Example 1b.

Sources & evidence

ORD record: ord-ae3f0af5cd3b42d986a1b3b1dd0066f5
Source dataset: uspto-grants-1983_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04380546

Reaction notes

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