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HRID1702212

反应详情

EQUATION

反应方程式

HRID 1702212 的结构方程式

REACTANTS

反应物

3
结构：BrCc1ccccc1
HCID7498

alpha-Bromotoluene

C7H7Br

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CC(C)(C)OC(=O)[C@@H]1CNC(=O)N1C(=O)OCc1ccccc1
HCID11067160

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)[C@@H]1CN(Cc2ccccc2)C(=O)N1C(=O)OCc1ccccc1
HCID56635970

未命名化合物

收率 75.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture of 9.6 g of tert.-butyl (4S)-3-benzyloxycarbonyl-2-oxo-imidazolidine-4-carboxylate, 8.3 g of potassium carbonate, 20 g of benzyl bromide and 200 ml of acetone is stirred at room temperature for 3 days. Then, the reaction mixture is treated in the same manner as described in Example 1-(2). 9.3 g of tert.-butyl (4S)-1-benzyl-3-benzyloxycarbonyl-2-oxo-imidazolidine-4-carboxylate are obtained as colorless syrup. Yield: 75.6%

WORKUP

后处理

  1. additionThen, the reaction mixture is treated in the same manner