反应详情

To a solution of 56 g of 2-methylamino-2',5-dichlorobenzophenone in 400 cc of ethyl acetate there are added an equal volume of ice and then 23 cc of bromoacetylbromide. After stirring overnight at room temperature, 300 cc of ethyl ether are added. The solvent layer is decanted, washed with 2 N caustic soda, and then washed with water until neutral. It is then dried over sodium sulfate, filtered, and evaporated to dryness. The residue is treated with petroleum ether and then recrystallized from ethyl acetate. In this way there are obtained 65 g of crystals; yield: 81%.

1. customThe solvent layer is decanted
2. washwashed with 2 N caustic soda
3. washwashed with water until neutral
4. dry with materialIt is then dried over sodium sulfate
5. filtrationfiltered
6. customevaporated to dryness
7. additionThe residue is treated with petroleum ether
8. customrecrystallized from ethyl acetate