Dimethyl Sulfoxide → (4-Isobutylphenyl)acetonitrile

HRID 1702466노트

반응식

HRID 1702466 반응식
[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Cl)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[C-:13]#[N:14].[Na+].CS(C)=O>O>[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][C:13]#[N:14])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 8929Sodium CyanideHCID 1812891-(Chloromethyl)-4-(2-methylpropyl)benzene

생성물 1

HCID 170426(4-Isobutylphenyl)acetonitrile수율 73.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

527 g of 4-isobutylbenzyl chloride, 153 g of sodium cyanide and 720 ml of dimethylsulfoxide are agitated for 6 hours at 40° C. The mixture is cooled and then diluted with water. An oily layer separates and is extracted with ether. The ether solution is subjected to fractionation and yields 367 g of 4-isobutylphenyl acetonitrile.

후처리

  1. temperatureThe mixture is cooled
  2. extractionAn oily layer separates and is extracted with ether

출처 및 근거

ORD 기록
ord-791c4d436ca54ab2b434ceb83553cca8
출처 데이터셋
uspto-grants-1983_04
특허 번호
US04381313

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